Compressol™ ProTab
Supplier: SPI Pharma
Product Applications: Chewable Tablet, DC Tablet, Probiotics,
Product Class: Excipient,
Product Categories: Nutraceutical, Pharmaceutical
Compressol™ ProTab
$0.00
Product Information
Superior compactability for high dosage
Compressol™ ProTab is a multifunctional soluble excipient platform designed for direct compression. It remains effective even with potent, sensitive, or fragile actives, delivering consistent performance, stability, and manufacturability across a wide range of tablet formats. This low-moisture binder allows tablets to be made at low compaction and still retain the function of sensitive active ingredients such as probiotics and multi-unit particle systems (MUPS).
Additional benefits of Compressol™ ProTab:
Looking to learn more about the next generation of direct compression? Watch the Technical Webinar Now!
How Compressol ProTab excels in the industry
High-Does Actives & Formulation Ease
- Handles poorly compactible APIs
- Enables high dose drug loads
- Dry alternative to wet granulation
- Minimizes moisture-related risks
Probiotic Viability
- Preserves sensitive strains
- Exceptionally low water activity
- Enables probiotic tablets, chewables & ODTs
Controlled Release & MUPS Compatibility
- Protects fragile pellets
- Low compression forces
- Maintains coating integrity
Versatility
- Sweet & water soluble
- Strong binding properties
- Ideal for effervescent & poorly soluble APIs
Formulating benefits of Compressol ProTab in applications include:
✔️ Tableting of difficult-to-compress pharmaceutical active ingredients
✔️ Less excipient used, reducing tablet size
✔️ Fully water-soluble for effervescent tablets
Application Examples:
Compressol™ ProTab is an effective solution for the following applications:
✅ Directly Compressible Tablets | ✅ Probiotic Tablets ✅ Pellet-based Drug Delivery | ✅ Chewable Tablets
Directly Compressible (DC) Tablets
DC tableting is often the top choice for making dosage forms. Still, challenges arise with certain actives, requiring additional binders, leading to larger tablets, or necessitating alternate technologies, such as capsule delivery. Moisture-sensitive actives create additional challenges.
KEY BENEFITS
• Produces tablets with low compressibility actives
• Compresses high-dose formulations
• A low moisture choice for sensitive actives
• Use with poor flow or low-density actives
Probiotic Tablets
Probiotic strains like Saccharomyces cerevisiae (boulardii) and Lactobacillus acidophilus are highly sensitive to processing conditions. Using low compression forces in tableting helps preserve cell viability.
KEY BENEFITS
• Maintains probiotic viability in tablets
• Reduces the required starting load of probiotic cultures
• Cost savings for manufacturers and final dosage forms
• Enables differentiated probiotic delivery formats
Pellet-Based Drug Delivery
Pellets with spherical cores, coated or layered with active ingredients, provide versatile options for advanced oral dosage forms such as taste masking and controlled drug release.
KEY BENEFITS
• Ensures coating integrity of coated pellets in MUPS tablets ex. Masking & Modified Release
• Produces MUPS tablets of higher tensile strength at low compression force with low friability
• Improved consistency of drug release in controlled-release tablets
• Reduced risk of dose dumping
Chewable Tablets
Compressol™ ProTab enables the development of robust chewable tablets from poorly compressible and poorly flowing powders, while also improving patient convenience and compliance.
KEY BENEFITS
• Reduced tablet weight without sacrificing strength
• Sugar-free and lactose-free formulation options
• Enables higher-dose single tablets
• Easy-to-chew tablets, even at higher weights (up to 2,500 mg)
• Allows single-tablet daily dose, eliminating the need for multiple capsules
Compressol™ ProTab excels where traditional excipients fall short.
Our team is ready to help you solve complex formulation challenges with the next generation of direct compression SPI’s Compressol™ ProTab.
