IMWITOR 988 is a penetration enhancer and a solvent.
IMWITOR 988
Glycerol Monocaprylate, Type I
Supplier: IOI Oleochemicals
Product Applications: Penetration enhancer, Tityptaotor,
Product Class: Excipient,
Product Category: Pharmaceutical
Supplier: IOI Oleochemicals
Product Applications: Penetration enhancer, Tityptaotor,
Product Class: Excipient,
Product Category: Pharmaceutical
IMWITOR 988
Product Information
IMWITOR 988 is a penetration enhancer and a solvent. Several scientific tests illustrate the ability to enhance the skin penetration of poorly soluble APIs. Both excipients, IMWITOR 988 & IMWITOR 742, are used in various dosage forms in amounts of 3–15%, depending on the kind and amount of active substance.
IMWITOR® 988 is a partial ester of caprylic acid and glycerol. Fatty acids and glycerol are derived from vegetable sources.
IMWITOR 988 is used in oral, topical, rectal, vaginal und nasal preparations in the amount of 3 – 15 %, depending on the kind and quantity of the active ingredients used. It acts as a solubilizer for poorly soluble drugs in oral administration forms (i.e. capsules). IMWITOR® 988 also functions as a penetration enhancer in topical drug forms. IMWITOR 988 is surface active and acts as a plasticizer in tablet coatings, as co-emulsifier in emulsions and as defoaming agent.
IMWITOR® 988 is a white, crystalline, pasty mass with a slight coconut odor and a bitter taste. Therefore a direct oral use is not recommended.
IMWITOR 988 melts at about 25°C to form an oily, yellowish liquid.
IMWITOR® 988 is readily soluble in natural fats and oils or MCT (f.i. MIGLYOL® 812 N), diethyl ether, n-hexane, ethanol and dispersible in water (about 10 %).
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