Mannogem® XL, is an innovative approach to mannitol designed to improve the formulation experience and enhance formulation performance. It is a multifunctional, compendial grade of DC spray-dried mannitol that provides superior binding and quick disintegration.
Mannogem® XL
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Supplier: SPI Pharma
Product Applications: Capsule, Chewable Tablet, DC Tablet, Effervescent, Lozenge, Orally Disintegrating Tablet (ODT), Orally Dispersible Powder (ODP), Soft-Chews, Tablet,
Product Class: Binder, Excipient,
Product Categories: Nutraceutical, Pharmaceutical
Supplier: SPI Pharma
Product Applications: Capsule, Chewable Tablet, DC Tablet, Effervescent, Lozenge, Orally Disintegrating Tablet (ODT), Orally Dispersible Powder (ODP), Soft-Chews, Tablet,
Product Class: Binder, Excipient,
Product Categories: Nutraceutical, Pharmaceutical
Mannogem® XL
Product Information
Mannogem XL is spray-dried grade Mannitol. It is a multifunctional, compendial grade of DC spray dried mannitol that provides superior binding and quick disintegration. Going beyond a standard diluent (filler) and performing as a binder with excellent disintegration, Mannogem XL enables the production of difficult to compress and problematic formulations. Uniquely engineered to provide productivity improvements from development to manufacture, resulting in major gains in final dosage form consistency. Greater manufacturing consistencies are provided through XL’s performance and tight particle size range. Mannogem XL utilizes the quality of mannitol including positive organoleptics, useful in the formulation of chewable, fast melts, and orally disintegrating tablets.
Quick Benefits Glance:
- Sphericity Imparts flow
- ~140 PSD D50 (μm)
- Porosity enhances compaction for more challenging formulations
- Highest compressibility grade and high flowability
- Retains fast disintegration
- Formulation simplification; smaller tablets; improved patient convenience
- Higher loading of active ingredients
Mannogem XL retains the positive qualities of compendial mannitol while boasting enhancements:
- 25% higher tablet hardness
- 38% quicker disintegration per tablet hardness
- 50% higher drug loading capability
- 200% improvement in friability at a low compression force
Compendial USP/NF mannitol
| Available Products | Product Details |
| Mannogem® Onyx | ~50 PSD D50 (μm) |
| Mannogem® Emerald | ~25 PSD D50 (μm) |
| Mannogem® XL | ~140 PSD D50 (μm) |
| Mannogem® Granular | ~480 PSD D50 (μm) |
| Mannogem® 2080 | ~320 PSD D50 (μm) |
| Mannogem® XL Opal | 160 µm |
| Mannogem® XL Ruby | 300 µm |
