WITEPSOL H series of hard fats are for use in suppositories.
WITEPSOL H Series
triglycerides, diglycerides, monoglycerides
Supplier: IOI Oleochemicals
Product Applications: Capsule, Chewable Tablet, Implants, Microencapsulation, Ovule, Pharma Excipients, SLN, Suppository,
Product Class: Excipient,
Product Categories: Nutraceutical, Pharmaceutical
Supplier: IOI Oleochemicals
Product Applications: Capsule, Chewable Tablet, Implants, Microencapsulation, Ovule, Pharma Excipients, SLN, Suppository,
Product Class: Excipient,
Product Categories: Nutraceutical, Pharmaceutical
WITEPSOL H Series
$0.00
Product Information
WITEPSOL® H hard fats mostly consist of triglycerides with a portion of, at most, 15% of diglycerides and not more than 1% of monoglycerides. They are characterized by a very small gap between the melting and solidification temperatures, have only a minor tendency to the post-hardening phenomenon (maximum 1.5 °C), and can be processed both with automatic casting machines and, on a small scale, using the cream melting process (precrystallization) at casting temperatures around the stated melting point. They include compounds having hydroxyl values (HV) between 0 and 5 which avoid interactions between the free OH groups and acidic active compounds (ASS, Diclofenac, etc.).
There are 7 grades of Hard fats in the WITEPSOL H series, we have broken them into three categories to help you select the right solution:
Sample each at the bottom
Compounds for suspension suppositories having a proportion of solid active compounds <25%
| Grade | Melting Point | HV | Composition Benefits |
| WITEPSOL® H35 | 33.5-35.5°C | 3 | |
| WITEPSOL® H5 | 34-36°C | 5 | Ideal for use with Codein, Streptokinase, Nystatin, Metronidazol, Dimenhydrinat, Diclofenac (Sodium) |
| WITEPSOL® H15 | 33.5-35.5°C | 5-15 | Best for acidic Actives, such as Lidocaine, Allantoin, Mesalazine, Acetaminophen, Fluocortolon, Bisacodyl, Ibuprofen, Paracetamol, Policresulen, Streptokinase, Hydrocortisone, Cinchocain Typically tested jointly to find preference with clients. See More |
Compounds for suspension suppositories having a proportion of solid active compounds >25%
| Grade | Melting Point | HV | Composition Benefits |
| WITEPSOL® H32 | 31-33°C | 3 | See More |
| WITEPSOL® H12 | 32-33.5°C | 5-15 | |
| WITEPSOL® H19 | 33.5-35.5°C | 20-30 | contains Glyceryl Ricinoleate as additive, non-compendial |
Compounds for suspension suppositories and lipophilic active compounds; For melting point correction
| Grade | Melting Point | HV | Composition Benefits |
| WITEPSOL® H37 | 36-38°C | 3 |
Explore More with this Informational Webinar from IOI Technical Team:
PROCESSING – BEST PRACTICES / CREAM MELTING
Melt Hard Fat to 60°C under stirring for ~15 mins, recommended to destroy the near states of grid structure and memory effect of fat crystals
• Cooling to ~ 45°C before introducing suspended actives
• Incorporate API under stirring
• Cool to appr. 5 °C above melt temperature prior to molding, bulk mixture should remain agitated
• Molds at room temperature
• Temperature delta between hard fat reservoir and molded suppositories (first cooling) should not exceed 15°
